Chatham-Kent police executed a search warrant at a home on Bloomfield Road in Chatham Wednesday night.
Police discovered $25,000 dollars worth of suspected fentanyl, cocaine, and methamphetamine.
They also discovered four firearms, and a large quantity of Canadian and American cash.
Two Chatham men aged 39 and 35, a 37 year old Chatham woman, and two men from the GTA were arrested and taken into custody.
The charges laid included possession for the purpose of trafficking, and unauthorized possession of a firearm.